TITLE PAGE	5
	COPYRIGHT PAGE	6
	CONTENTS	7
	PREFACE	13
	CHAPTER 1 MOLECULAR BIOLOGY OF THE CELL	15
	COMPARTMENTALIZATION OF THE CELL	15
	THE NUCLEUS	15
	GENE TRANSCRIPTION AND MESSENGER RNA TRANSLATION: THE PRODUCTION AND JOURNEY OF mRNA	17
	DNA MUTATIONS CAN ALTER PROTEIN SYNTHESIS BY A NUMBER OF MECHANISMS	20
	TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION	20
	CIS?ELEMENTS AND TRANSCRIPTION FACTORS	22
	CHROMATIN AND EPIGENETIC CONTROL OF GENE EXPRESSION	23
	TRANSCRIPTION FACTORS, CONTROL OF GENE EXPRESSION, AND LINEAGE COMMITMENT	28
	MICRO?RNAs	30
	REGULATORY NONCODING RNAs	30
	DNA REPLICATION AND TELOMERES	30
	MUTATIONS AND HOW THEY RESULT IN DISEASE	31
	CELL CYCLE	33
	APOPTOSIS	34
	ORGANELLES IN CELLS	35
	MITOCHONDRIA	35
	LINK BETWEEN METABOLISM AND GENE EXPRESSION	36
	REMOVAL OF CIRCULATING AND CELLULAR DEBRIS BY LYSOSOMES	40
	PROTEIN UBIQUITINATION	40
	CHAPTER 2 HEMATOPOIESIS	41
	SITES OF HEMATOPOIESIS	41
	ROAD MAPS OF HEMATOPOIESIS	41
	CELLULAR PATHWAYS AS HSCs DIFFERENTIATE INTO TERMINALLY MATURE CELLS	41
	TRANSCRIPTIONAL CONTROL OF HEMATOPOIESIS	46
	THE HEMATOPOIETIC NICHE	47
	CHAPTER 3 GROWTH FACTOR SIGNALING	51
	SIGNALING AT DIFFERENT STAGES OF HEMATOPOIESIS	51
	CYTOKINE RECEPTORS	52
	SIGNALING PATHWAYS DOWNSTREAM OF RECEPTORS	53
	WNT PATHWAY	53
	CYTOKINE SIGNALING PATHWAYS	54
	THE RAS/MAP KINASE PATHWAY	55
	PHOSPHATIDYLINOSITOL 3?KINASE PATHWAY	55
	JAK?STAT PATHWAY	55
	MUTATIONS IN SIGNALING COMPONENTS LEADING TO CLONAL HEMATOLOGIC DISORDERS	60
	CHAPTER 4 ERYTHROPOIESIS AND EXAMINATION OF THE PERIPHERAL BLOOD AND BONE MARROW	61
	ERYTHROPOIESIS	61
	EXAMINATION OF PERIPHERAL BLOOD AND THE BONE MARROW	63
	ERYTHROID CELLS IN THE BONE MARROW AND PERIPHERAL BLOOD	63
	CHAPTER 5 HYPOCHROMIC ANEMIAS	67
	IRON METABOLISM	67
	IRON ABSORPTION	69
	HEPCIDIN	69
	IRON HOMEOSTASIS	69
	IRON-DEFICIENCY ANEMIA	69
	BLOOD AND BONE MARROW APPEARANCES	70
	CAUSES OF IRON DEFICIENCY	71
	IRON?REFRACTORY IRON?DEFICIENCY ANEMIA (IRIDA)	76
	SIDEROBLASTIC ANEMIA	76
	CONGENITAL SIDEROBLASTIC ANEMIA	77
	ALCOHOL	81
	LEAD POISONING	81
	DIFFERENTIAL DIAGNOSIS OF HYPOCHROMIC MICROCYTIC ANEMIAS	82
	CHAPTER 6 THE PORPHYRIAS AND IRON OVERLOAD	83
	CONGENITAL ERYTHROPOIETIC PORPHYRIA	83
	CONGENITAL ERYTHROPOIETIC PROTOPORPHYRIA	85
	IRON OVERLOAD	85
	GENETIC HEMOCHROMATOSIS	85
	RARE CAUSES OF IRON OVERLOAD	88
	HEREDITARY HYPERFERRITINEMIA WITH AUTOSOMAL DOMINANT CONGENITAL CATARACT SYNDROME	88
	CHAPTER 7 MEGALOBLASTIC ANEMIAS	90
	CLINICAL FEATURES	91
	BLOOD COUNT AND BLOOD FILM APPEARANCES	93
	BONE MARROW APPEARANCES	95
	CAUSES OF MEGALOBLASTIC ANEMIA	95
	VITAMIN B12 DEFICIENCY	95
	FOLATE DEFICIENCY	98
	ABNORMALITIES OF VITAMIN B12 OR FOLATE METABOLISM	98
	OTHER CAUSES	100
	CHAPTER 8 HEMOLYTIC ANEMIAS	103
	HEREDITARY HEMOLYTIC ANEMIA	105
	NORMAL RED CELL MEMBRANE	105
	RED CELL BLOOD GROUP ANTIGENS	105
	HEREDITARY SPHEROCYTOSIS	106
	HEREDITARY ELLIPTOCYTOSIS	106
	NORMAL RED CELL METABOLISM	108
	HEMOLYTIC ANEMIAS ASSOCIATED WITH INHERITED DEFECTS OF ENZYMES	110
	ACQUIRED HEMOLYTIC ANEMIA	113
	AUTOIMMUNE HEMOLYTIC ANEMIAS	113
	EVANS SYNDROME	115
	DRUG?INDUCED IMMUNE HEMOLYTIC ANEMIA	115
	ISOIMMUNE HEMOLYTIC ANEMIA	115
	RED CELL FRAGMENTATION SYNDROMES	115
	SECONDARY HEMOLYTIC ANEMIAS	116
	PAROXYSMAL NOCTURNAL HEMOGLOBINURIA	117
	OTHER HEMOLYTIC ANEMIAS	118
	CHAPTER 9 GENETIC DISORDERS OF HEMOGLOBIN	120
	THALASSEMIA	120
	??THALASSEMIA MAJOR	122
	??THALASSEMIA INTERMEDIA (NONTRANSFUSION?DEPENDENT THALASSEMIA)	129
	??THALASSEMIA TRAIT	131
	??THALASSEMIA WITH A DOMINANT PHENOTYPE	131
	ANTENATAL DIAGNOSIS	132
	??THALASSEMIA	132
	X?LINKED ??THALASSEMIA AND MENTAL RETARDATION SYNDROME	133
	STRUCTURAL HEMOGLOBIN VARIANTS	136
	SICKLE CELL ANEMIA	136
	OTHER STRUCTURAL HEMOGLOBIN DEFECTS	142
	F?CELLS	142
	METHEMOGLOBINEMIA	143
	CHAPTER 10 BENIGN DISORDERS OF PHAGOCYTES	144
	GRANULOPOIESIS AND MONOCYTE PRODUCTION	144
	NEUTROPHILS (POLYMORPHS)	145
	MONONUCLEAR PHAGOCYTIC SYSTEM	147
	RETICULOENDOTHELIAL SYSTEM	147
	HEREDITARY VARIATION IN WHITE CELL MORPHOLOGY	151
	PELGER–HUËT ANOMALY	151
	MAY–HEGGLIN ANOMALY	152
	CHÉDIAK–HIGASHI SYNDROME	153
	ALDER (ALDER–REILLY) ANOMALY	153
	MYELOPEROXIDASE DEFICIENCY	153
	NEUTROPHIL?SPECIFIC GRANULE DEFICIENCY	153
	MUCOPOLYSACCHARIDOSES VI AND VII	153
	DORFMAN–CHANARIN SYNDROME	154
	LYSINURIC PROTEIN INTOLERANCE	154
	DISORDERS OF PHAGOCYTIC FUNCTION	154
	CHRONIC GRANULOMATOUS DISEASE	154
	PAPILLON–LEFEVRE SYNDROME	155
	LAZY LEUKOCYTE SYNDROME	155
	LEUKOCYTE ADHESION DEFICIENCY	155
	CARD9 DEFICIENCY	156
	LEUKOCYTOSIS	156
	NEUTROPHIL LEUKOCYTOSIS (NEUTROPHILIA)	156
	HYPERTHERMIA	157
	EOSINOPHIL LEUKOCYTOSIS (EOSINOPHILIA)	157
	MONOCYTOSIS AND BASOPHIL LEUKOCYTOSIS	157
	LEUKEMOID REACTION	158
	LEUKOERYTHROBLASTIC REACTION	159
	NEUTROPENIA	160
	SEVERE CONGENITAL NEUTROPENIA	160
	IDIOPATHIC CYTOPENIAS OF UNDETERMINED SIGNIFICANCE	162
	MYELOKATHEXIS	163
	WHIM SYNDROME	163
	LYSOSOMAL STORAGE DISEASES	164
	GAUCHER DISEASE	164
	NIEMANN–PICK DISEASE	165
	SEA?BLUE HISTIOCYTE SYNDROME	167
	CHAPTER 11 BENIGN DISORDERS OF LYMPHOCYTES AND PLASMA CELLS	169
	T CELLS	169
	PD?1–PD?L1	170
	CHIMERIC ANTIGEN RECEPTOR CELLS	171
	B CELLS	171
	NATURAL KILLER CELLS	174
	LYMPHOCYTE PROLIFERATION AND DIFFERENTIATION	176
	SOMATIC HYPERMUTATION IN NORMAL B CELLS	178
	LYMPHOCYTE CIRCULATION	178
	COMPLEMENT	179
	LYMPHOCYTOSIS	179
	INFECTIOUS MONONUCLEOSIS	179
	LYMPHADENOPATHY	181
	KIKUCHI DISEASE	182
	SINUS HISTIOCYTOSIS WITH MASSIVE LYMPHADENOPATHY (ROSAI–DORFMAN DISEASE) (SEE ALSO CHAPTER 24)	182
	PRIMARY IMMUNODEFICIENCY DISORDERS	182
	ACQUIRED IMMUNODEFICIENCY SYNDROME	184
	AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME	194
	CHAPTER 12 APLASTIC AND DYSERYTHROPOIETIC ANEMIAS	199
	APLASTIC ANEMIA	199
	ACQUIRED APLASTIC ANEMIA	199
	INHERITED APLASTIC ANEMIA	200
	BONE MARROW APPEARANCES	205
	RED CELL APLASIA	207
	DIAMOND–BLACKFAN ANEMIA	207
	CONGENITAL DYSERYTHROPOIETIC ANEMIAS	209
	CHAPTER 13 THE HEMATOLOGIC NEOPLASMS: LABORATORY TECHNIQUES AND ACUTE MYELOID LEUKEMIA	212
	DIAGNOSTIC TECHNIQUES	212
	IMMUNOHISTOCHEMISTRY	212
	FLOW CYTOMETRIC IMMUNOPHENOTYPING	213
	CYTOGENETIC ANALYSIS	215
	FLUORESCENCE IN SITU HYBRIDIZATION	215
	MOLECULAR GENETIC ANALYSIS	215
	ACUTE MYELOID LEUKEMIA	222
	CLASSIFICATION	226
	CLINICAL FEATURES	226
	MICROSCOPIC APPEARANCES	228
	WHO 2016 SUBGROUPS	228
	CLASSIFICATION OF MYELOID NEOPLASMS WITH GERMLINE PREDISPOSITION	239
	ACUTE LEUKEMIAS OF AMBIGUOUS LINEAGE	243
	SPECIFIC DIAGNOSTIC ASPECTS IN AML	243
	CHAPTER 14 ACUTE LYMPHOBLASTIC LEUKEMIA	255
	CLASSIFICATION	255
	B?LYMPHOBLASTIC LEUKEMIA/LYMPHOMA, BCR?ABL1?LIKE	255
	B?ALL WITH INTRACHROMOSOMAL AMPLIFICATION OF CHROMOSOME 21	256
	T?LYMPHOBLASTIC LEUKEMIA/LYMPHOMA	256
	EARLY T?CELL PRECURSOR ALL	256
	ACUTE NATURAL KILLER CELL LEUKEMIA	256
	CLINICAL FEATURES	256
	MICROSCOPIC APPEARANCES	258
	IMMUNOLOGY	260
	CYTOGENETICS	261
	FLUORESCENCE IN SITU HYBRIDIZATION	262
	MOLECULAR FINDINGS	262
	B?ALL	262
	T?ALL	262
	MINIMAL RESIDUAL DISEASE	264
	FLOW CYTOMETRY	264
	MOLECULAR METHODS	266
	CHAPTER 15 MYELODYSPLASTIC SYNDROMES	270
	CLINICAL FEATURES	270
	MICROSCOPIC FEATURES	270
	CYTOGENETIC ABNORMALITIES	277
	MOLECULAR GENETICS	277
	SPLICING FACTORS	280
	EPIGENETIC REGULATORS	280
	COHESINS	280
	TRANSCRIPTION FACTORS	282
	SIGNAL TRANSDUCTION	282
	MOLECULAR GENETICS DURING FOLLOW?UP	282
	MIRAGE SYNDROME	282
	CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL	283
	CHAPTER 16 MYELOPROLIFERATIVE NEOPLASMS	285
	CHRONIC MYELOID LEUKEMIA, BCR?ABL1+	285
	CLINICAL FEATURES	286
	ACCELERATED PHASE	287
	BLAST TRANSFORMATION	290
	CHRONIC NEUTROPHILIC LEUKEMIA	291
	THE NONLEUKEMIC MYELOPROLIFERATIVE DISEASES	291
	ETIOLOGY	293
	POLYCYTHEMIA VERA	296
	ESSENTIAL THROMBOCYTHEMIA	297
	PRIMARY MYELOFIBROSIS	302
	LEUKEMIC TRANSFORMATION OF POLYCYTHEMIA VERA AND MYELOFIBROSIS	309
	CHRONIC EOSINOPHILIC LEUKEMIA, NOT OTHERWISE SPECIFIED	314
	MYELOPROLIFERATIVE DISORDER UNCLASSIFIABLE	314
	CHAPTER 17 MASTOCYTOSIS, MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND SPECIFIC CYTOGENETIC REARRANGEMENTS, MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS	316
	MASTOCYTOSIS	316
	TYPES OF MASTOCYTOSIS	317
	PROGNOSIS	323
	PARANEOPLASTIC PEMPHIGUS	323
	MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND ABNORMALITIES OF PDGFRA, PDGFRB OR FGFR1, OR WITH PCM1-JAK2	323
	CHRONIC MYELOMONOCYTIC LEUKEMIA	326
	ATYPICAL CHRONIC MYELOID LEUKEMIA, BCR?ABL1?	326
	MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS WITH RING SIDEROBLASTS AND THROMBOCYTOSIS	326
	JUVENILE MYELOMONOCYTIC LEUKEMIA	328
	NOONAN SYNDROME	328
	NEUROFIBROMATOSIS 1	329
	CHAPTER 18 CHRONIC LYMPHOCYTIC LEUKEMIA AND OTHER MATURE B? AND T?CELL LEUKEMIAS	331
	MATURE B-CELL LEUKEMIAS	331
	CHRONIC LYMPHOCYTIC LEUKEMIA	331
	B?CELL PROLYMPHOCYTIC LEUKEMIA	339
	HAIRY CELL LEUKEMIA	341
	MATURE T-CELL LEUKEMIAS	342
	T?CELL PROLYMPHOCYTIC LEUKEMIA	342
	T?CELL LARGE GRANULAR LYMPHOCYTIC LEUKEMIA	344
	ADULT T?CELL LEUKEMIA/LYMPHOMA	347
	AGGRESSIVE NK?CELL LEUKEMIA	347
	CHAPTER 19 SMALL B?CELL LYMPHOMAS	349
	EPIDEMIOLOGY	350
	ETIOLOGIC FACTORS	350
	GENETIC AND MOLECULAR ABNORMALITIES	351
	CLINICAL FEATURES AND DIAGNOSIS	351
	IMAGING	355
	DIAGNOSIS	356
	LYMPHOPLASMACYTIC LYMPHOMA/ WALDENSTRÖM MACROGLOBULINEMIA	359
	MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE IGM+	360
	HEAVY CHAIN DISEASES	360
	SPLENIC MARGINAL ZONE LYMPHOMA	362
	EXTRANODAL MARGINAL ZONE LYMPHOMA OF MUCOSA?ASSOCIATED LYMPHOID TISSUE (MALT LYMPHOMA)	363
	NODAL MARGINAL ZONE B?CELL LYMPHOMA	365
	FOLLICULAR LYMPHOMA	366
	OTHER SUBTYPES OF FOLLICULAR LYMPHOMAS	369
	MANTLE CELL LYMPHOMA	370
	CHAPTER 20 AGGRESSIVE MATURE B?CELL NEOPLASMS	375
	DIFFUSE LARGE B?CELL LYMPHOMA, NOS	375
	T?CELL/HISTIOCYTIC?RICH LARGE B?CELL LYMPHOMA	379
	PRIMARY CUTANEOUS DIFFUSE LARGE B?CELL LYMPHOMA, LEG TYPE	379
	LYMPHOMATOID GRANULOMATOSIS	379
	PRIMARY MEDIASTINAL (THYMIC) LARGE B?CELL LYMPHOMA	379
	INTRAVASCULAR LARGE B?CELL LYMPHOMA	380
	ALK?POSITIVE DIFFUSE LARGE B?CELL LYMPHOMA	380
	PLASMABLASTIC LYMPHOMA	384
	PRIMARY EFFUSION LYMPHOMA AND OTHER HHV8?RELATED DISORDERS	384
	BURKITT LYMPHOMA	385
	HIGH GRADE B?CELL LYMPHOMA	386
	CHAPTER 21 MYELOMA AND RELATED NEOPLASMS	390
	MULTIPLE (PLASMA CELL) MYELOMA	390
	PLASMA CELL LEUKEMIA	397
	PROGNOSIS	397
	SMOLDERING (ASYMPTOMATIC) MYELOMA	397
	OTHER PLASMA CELL TUMORS	397
	SOLITARY PLASMACYTOMA OF BONE	397
	EXTRAOSSEOUS (EXTRAMEDULLARY) PLASMACYTOMA	397
	HYPERVISCOSITY SYNDROME	398
	OTHER CAUSES OF SERUM M?PROTEINS	398
	MONOCLONAL GAMMOPATHY OF UNCERTAIN SIGNIFICANCE	401
	CRYOGLOBULINEMIA	403
	AMYLOIDOSIS	403
	PRIMARY (AL) AMYLOIDOSIS	406
	LOCALIZED AL AMYLOIDOSIS	406
	REACTIVE SYSTEMIC (AA) AMYLOIDOSIS	408
	LIGHT CHAIN DEPOSITION DISEASE	408
	CHAPTER 22 PERIPHERAL T? AND NK?CELL NEOPLASMS	413
	MATURE T? AND NK?CELL NEOPLASMS	413
	EPSTEIN–BARR VIRUS POSITIVE T?CELL LYMPHOPROLIFERATIVE DISEASES OF CHILDHOOD	413
	CHRONIC ACTIVE EBV INFECTION: HYDROA VACCINIFORME?LIKE LYMPHOPROLIFERATIVE DISORDER	413
	SYSTEMIC EBV+ T?CELL LYMPHOMA OF CHILDHOOD	414
	EXTRANODAL NK?/T?CELL LYMPHOMA, NASAL TYPE	414
	ENTEROPATHY?ASSOCIATED T?CELL LYMPHOMA	415
	HEPATOSPLENIC T?CELL LYMPHOMA	416
	PRIMARY CUTANEOUS T?CELL LYMPHOMAS	418
	SUBCUTANEOUS PANNICULITIS?LIKE T?CELL LYMPHOMA	418
	MYCOSIS FUNGOIDES	419
	FOLLICULOTROPHIC MYCOSIS FUNGOIDES (MYCOSIS FUNGOIDES?ASSOCIATED FOLLICULAR MUCINOSIS)	420
	PAGETOID RETICULOSIS	420
	GRANULOMATOUS SLACK SKIN DISEASE	420
	SÉZARY SYNDROME	421
	PRIMARY CUTANEOUS CD30+ T?CELL LYMPHOPROLIFERATIVE DISORDERS	422
	LYMPHOMATOID PAPULOSIS	423
	PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA	423
	PRIMARY CUTANEOUS ?? T?CELL LYMPHOMA	424
	PRIMARY CUTANEOUS AGGRESSIVE EPIDERMOTROPHIC CD8+ T?CELL LYMPHOMA (PROVISIONAL CATEGORY)	424
	PRIMARY CUTANEOUS SMALL/MEDIUM CD4+ T?CELL LYMPHOPROLIFERATIVE DISORDER (PROVISIONAL CATEGORY)	425
	PERIPHERAL T?CELL LYMPHOMA, NOT OTHERWISE SPECIFIED	425
	ANGIOIMMUNOBLASTIC T?CELL LYMPHOMA	426
	ANAPLASTIC LARGE CELL LYMPHOMA, ALK POSITIVE	427
	ANAPLASTIC LARGE CELL LYMPHOMA, ALK NEGATIVE	428
	CHAPTER 23 HODGKIN LYMPHOMA	432
	PRESENTATION AND EVOLUTION	432
	HISTOLOGY	432
	HODGKIN REED–STERNBERG CELL	433
	CLASSIFICATION OF HODGKIN LYMPHOMA	435
	NODULAR SCLEROSING HODGKIN LYMPHOMA	435
	MIXED CELLULARITY HODGKIN LYMPHOMA	436
	LYMPHOCYTE?RICH CLASSIC HODGKIN LYMPHOMA	436
	LYMPHOCYTE?DEPLETED HODGKIN LYMPHOMA	437
	NODULAR LYMPHOCYTE?PREDOMINANT HODGKIN LYMPHOMA	437
	STAGING TECHNIQUES	438
	DEAUVILLE SCORE	441
	PROGNOSTIC FACTORS	446
	CHAPTER 24 HISTIOCYTIC DISORDERS	448
	HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HEMOPHAGOCYTIC SYNDROME)	448
	XANTHOGRANULOMA	449
	ROSAI–DORFMAN DISEASE	449
	HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS	453
	HISTIOCYTIC SARCOMA	453
	LANGERHANS CELL HISTIOCYTOSIS	453
	LANGERHANS CELL SARCOMA	458
	INDETERMINATE DENDRITIC CELL TUMOR	458
	INTERDIGITATING DENDRITIC CELL SARCOMA	458
	FOLLICULAR DENDRITIC CELL SARCOMA	460
	FIBROBLASTIC RETICULAR CELL TUMOR	461
	DISSEMINATED JUVENILE XANTHOGRANULOMA	461
	ERDHEIM–CHESTER DISEASE	461
	BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM	462
	CHAPTER 25 STEM CELL TRANSPLANTATION	465
	HUMAN LEUKOCYTE ANTIGEN SYSTEM	465
	HUMAN LEUKOCYTE ANTIGEN NOMENCLATURE	465
	TYPING OF HUMAN LEUKOCYTE ANTIGENS	466
	OTHER HUMAN LEUKOCYTE ANTIGENS	466
	STEM CELL TRANSPLANTATION	466
	NONMYELOABLATIVE (REDUCED INTENSITY) TRANSPLANTS	467
	DONOR LEUKOCYTES	469
	COMPLICATIONS OF STEM CELL TRANSPLANTS	471
	GRAFT?VERSUS?HOST DISEASE	473
	POST?TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS	477
	CHAPTER 26 NORMAL HEMOSTASIS, PLATELET PRODUCTION AND FUNCTION	482
	THE COAGULATION CASCADE	484
	REGULATION OF COAGULATION	484
	MEGAKARYOCYTE AND PLATELET PRODUCTION	486
	PLATELET AND VON WILLEBRAND FACTOR FUNCTION	489
	CHAPTER 27 VASCULAR AND PLATELET BLEEDING DISORDERS	493
	VASCULAR BLEEDING DISORDERS	493
	HEREDITARY HEMORRHAGIC TELANGIECTASIA (OSLER–WEBER–RENDU SYNDROME)	493
	EHLERS–DANLOS SYNDROME	493
	SENILE PURPURA	493
	SCURVY	493
	PURPURA ASSOCIATED WITH PROTEIN DEPOSITION	493
	IMMUNE?MEDIATED VESSEL WALL PURPURAS	494
	PLATELET BLEEDING DISORDERS	494
	THROMBOCYTOPENIA	494
	DISORDERS OF PLATELET FUNCTION	501
	CHAPTER 28 INHERITED AND ACQUIRED COAGULATION DISORDERS	508
	HEREDITARY COAGULATION DISORDERS	508
	HEMOPHILIA	508
	VON WILLEBRAND DISEASE	517
	OTHER HEREDITARY COAGULATION DISORDERS	517
	ACQUIRED COAGULATION DISORDERS	518
	LIVER DISEASE	518
	OVERDOSAGE WITH ANTICOAGULANTS	519
	DISSEMINATED INTRAVASCULAR COAGULATION	519
	ACQUIRED COAGULATION FACTOR INHIBITOR	521
	THROMBOELASTOMETRY AND THROMBOELASTOGRAPHY	523
	CHAPTER 29 THROMBOSIS AND ANTITHROMBOTIC THERAPY	524
	ATHEROTHROMBOSIS	524
	VENOUS THROMBOSIS	524
	THROMBOPHILIA	524
	ACQUIRED RISK FACTORS FOR VENOUS THROMBOSIS	529
	ANTIPHOSPHOLIPID SYNDROME	529
	DIAGNOSIS OF VENOUS THROMBOSIS	529
	CLINICAL PROBABILITY ASSESSMENT	529
	DIAGNOSIS OF PULMONARY EMBOLUS	530
	CLINICAL ASSESSMENT	530
	ANTIPLATELET DRUGS	533
	ASPIRIN	533
	DIPYRIDAMOLE (PERSANTIN)	533
	ADP RECEPTOR INHIBITORS	533
	GLYCOPROTEIN IIB/IIIA INHIBITORS	533
	PROSTACYCLIN	534
	ANTICOAGULANT THERAPY	534
	HEPARIN	534
	WARFARIN	536
	INDIRECT FACTOR Xa INHIBITORS	537
	DIRECT FACTOR Xa INHIBITORS	537
	DIRECT THROMBIN INHIBITORS	537
	FIBRINOLYTIC AGENTS	537
	POST-THROMBOTIC SYNDROME	541
	CHAPTER 30 HEMATOLOGIC ASPECTS OF SYSTEMIC DISEASES	542
	ANEMIA OF CHRONIC DISORDERS	542
	MALIGNANT DISEASES (OTHER THAN LEUKEMIAS, LYMPHOMAS, HISTIOCYTIC AND MYELOPROLIFERATIVE DISORDERS)	543
	RHEUMATOID ARTHRITIS AND OTHER CONNECTIVE TISSUE DISEASES	544
	RENAL FAILURE	547
	LIVER DISEASE	547
	HYPOTHYROIDISM	552
	INFECTIONS	553
	BACTERIAL INFECTIONS	553
	VIRAL INFECTIONS	555
	PARASITIC INFECTIONS DIAGNOSED IN BLOOD	556
	MARROW INVOLVEMENT IN OTHER INFECTIONS	556
	GRANULOMATOUS INFLAMMATION	556
	SARCOIDOSIS	556
	OTHER GRANULOMAS	557
	OSTEOPETROSIS (ALBERS–SCHÖNBERG OR MARBLE BONE DISEASE)	557
	ANOREXIA NERVOSA	558
	CYSTINOSIS	558
	PRIMARY OXALURIA	561
	CHAPTER 31 PARASITIC DISORDERS	562
	MALARIA	562
	EFFECTS OF MALARIA ON VARIOUS ORGANS	563
	COMPARATIVE METHODS FOR MALARIA DIAGNOSIS	563
	RESISTANCE TO ANTIMALARIAL THERAPY	566
	TOXOPLASMOSIS	566
	BABESIOSIS	566
	TRYPANOSOMIASIS	567
	BANCROFTIAN FILARIASIS	567
	LOIASIS	568
	BARTONELLOSIS	568
	RELAPSING FEVER	569
	CHAPTER 32 BLOOD TRANSFUSION	570
	RED CELL ANTIGENS	570
	RED CELL ANTIBODIES	571
	ABO SYSTEM	571
	RH SYSTEM	572
	BLOOD GROUPING AND CROSS?MATCHING	573
	RED CELL COMPONENTS	573
	CLINICAL BLOOD TRANSFUSION	574
	COMPLICATIONS OF BLOOD TRANSFUSION	574
	INFECTIONS	575
	IRON OVERLOAD	577
	TRANSFUSION?RELATED ACUTE LUNG INJURY	577
	GRAFT?VERSUS?HOST DISEASE	577
	OTHER BLOOD COMPONENTS	578
	PLATELET CONCENTRATES	578
	LEUKOCYTES	578
	FRESH FROZEN PLASMA	579
	PLASMA DERIVATIVES	579
	APPENDIX 2016 WORLD HEALTH ORGANIZATION CLASSIFICATION OF LYMPHOID AND MYELOID NEOPLASMS	581
	INDEX	585
	EULA	600